The best evidence on the efficacy of medical interventions is provided by high-quality trials summarized in high-quality systematic reviews or meta-analyses. The methodological quality of studies included in a systematic review can have a substantial impact on the estimates of the treatment effect and therefore on the conclusions of such a review. But what is the empirical evidence to support quality assessment of randomized clinical trials (RCTs)? We elaborate on questions such as: what is the concept of quality of individual studies (RCTs), can quality be measured validly and reliably? Plans for future research on this issue are proposed. Copyright

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Journal Journal of Clinical Epidemiology
Verhagen, A.P, de Vet, H.C.W, de Bie, R.A, Boers, M, & van den Brandt, P.A. (2001). The art of quality assessment of RCTs included in systematic reviews. Journal of Clinical Epidemiology (Vol. 54, pp. 651–654). doi:10.1016/S0895-4356(00)00360-7