2001-08-31
Role of fas-ligand in age-related maculopathy not established
Publication
Publication
American Journal of Ophthalmology , Volume 132 - Issue 3 p. 437- 439
PURPOSE: Fas-ligand expression on retinal pigment epithelium is hypothesized to have an inhibitory effect on human ocular neovascularization. METHODS: We studied Fas-ligand expression in the aging retinal pigment epithelium and in early and late stages of age-related maculopathy. Immunohistochemistry with antibodies against Fas-ligand was performed on paraffin-embedded sections of 23 human eye bank eyes (aged 45 to 96 years) and 12 eyes with exudative age-related maculopathy. RESULTS: Fas-ligand expression in retinal pigment epithelium was not related to age or to the presence of early age-related maculopathy. Furthermore, Fas-ligand expression in retinal pigment epithelium was similar in subretinal and subretinal pigment epithelium choroidal neovascular membranes. CONCLUSION: It appears to be unlikely that Fas-ligand expressed on retinal pigment epithelium controls the extension of choroidal neovascular membranes from subretinal pigment epithelium to subretinal. Copyright
Additional Metadata | |
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doi.org/10.1016/S0002-9394(01)01011-X, hdl.handle.net/1765/54560 | |
American Journal of Ophthalmology | |
Organisation | Department of Pathology |
Lambooij, A., Kliffen, M., Mooy, C., & Kuijpers, R. (2001). Role of fas-ligand in age-related maculopathy not established. American Journal of Ophthalmology, 132(3), 437–439. doi:10.1016/S0002-9394(01)01011-X |