2006
Targeting the IL-15 pathway to prevent rejection after organ transplantation
Publication
Publication
Transplantation Reviews , Volume 20 - Issue 1 p. 28- 33
Interleukin 15 regulates a variety of cellular functions, including the actions of dendritic cells, T cells, and natural killer cells. In particular, IL-15 is an important growth and survival factor for natural killer cells, memory cells, and regulatory T cells. After organ transplantation, IL-15 is expressed in acutely and chronically rejected grafts. These IL-15-mediated antidonor responses are inadequately inhibited by most of the currently prescribed immunosuppressive drugs. Therefore, strategies directed toward the IL-15 pathway are warranted; preliminary data on animal transplant models already show that targeting the IL-15 pathway indeed can reduce the incidence of rejection. Agents that block IL-15 action may provide a new perspective for the treatment of allogeneic responses in patients after transplantation.
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| doi.org/10.1016/j.trre.2006.02.002, hdl.handle.net/1765/54742 | |
| Transplantation Reviews | |
| Organisation | Department of Internal Medicine |
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Baan, C., & Weimar, W. (2006). Targeting the IL-15 pathway to prevent rejection after organ transplantation. Transplantation Reviews (Vol. 20, pp. 28–33). doi:10.1016/j.trre.2006.02.002 |
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