2006-09-01
Association between the CHEK2*1100delC germ line mutation and estrogen receptor status
Publication
Publication
International Journal of Gynecological Cancer , Volume 16 - Issue SUPPL. 2 p. 552- 555
Already published data were further analyzed regarding the association between the CHEK2*1100delC germ line mutation and estrogen receptor (ER) status in patients with breast cancer. The CHEK2*1100delC mutation was more prevalent among the patients with a positive ER status (4.2% versus 1.0%). An ER-negative status was beside CHEK2*1100delC mutation and independently associated with an earlier of age onset of breast cancer. There was a trend that an ER-negative status, beside the presence of a CHEK2*1100delC mutation, was associated with a worse disease-free survival. There might be an association between ER status and a CHEK2*1100delC mutation. More studies with larger number of patients are needed to further investigate the relation between CHEK2*1100delC and ER status.
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| doi.org/10.1111/j.1525-1438.2006.00694.x, hdl.handle.net/1765/54794 | |
| International Journal of Gynecological Cancer | |
| Organisation | Department of Clinical Genetics |
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de Bock, G., Mourits, M., Schutte, M., Krol-Warmerdam, E., Seynaeve, C., Blom, J., … Klijn, J. (2006). Association between the CHEK2*1100delC germ line mutation and estrogen receptor status. In International Journal of Gynecological Cancer (Vol. 16, pp. 552–555). doi:10.1111/j.1525-1438.2006.00694.x |
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