Studies of the pathophysiology of acute myocardial infarction (AMI) have shown that in most pa- tients a thrombus forms over a ruptured ather- oma in the infarct-related coronary artery and obstructs the artery.

Circulation (Baltimore)
Erasmus MC: University Medical Center Rotterdam

Schlant, R.C, O'Rourke, R.A, Collen, D, Kennedy, J.W, Kuschnir, E, Meyer, J, … Sleight, P. (1994). Reperfusion in acute myocardial infarction. Circulation (Baltimore), 90, 2091–2102. Retrieved from