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D.B. Zhao (Dong),
Z.M. Chen (Z.),
H.C. Pan (H.),
J. Bahi (J.),
M. Reid (M.),
M. Spittle (M.),
G.P. Deutsch (G.),
F. Senanayake (F.),
D.L.W. Kwong (D. L W),
A.C. Bianco (Antonio ),
C. Carlomagno (C.),
M. de Laurentiis (M.),
S. de Placido (S.),
A.U. Buzdar (A.),
T. Smith (T.),
J. Bergh (Jonas),
L. Holmberg (Lars),
A. Liljegren (Annelie),
J. Nilsson (J.),
M. Seifert (M.),
P. Sevelda (P.),
C.C. Zielinsky (C.),
R.B. Buchanan (R.),
M. Cross (M.),
G.T. Royle (G.),
J.A. Dunn (J.),
R.K. Hills (R.),
M. Lee (M.),
J. Morrison (Jonathan),
D. Spooner (D.),
A. Litton (A.),
R.T. Chlebowski (R.)
and
H. Caffier (H.)
2005-12-17
Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival
Publication
Publication
An overview of the randomised trials
The Lancet , Volume 366 - Issue 9503 p. 2087- 2106
Background: In early breast cancer, variations in local treatment that substantially affect the risk of locoregional
recurrence could also affect long-term breast cancer mortality. To examine this relationship, collaborative metaanalyses
were undertaken, based on individual patient data, of the relevant randomised trials that began by 1995.
Methods: Information was available on 42 000 women in 78 randomised treatment comparisons (radiotherapy vs no
radiotherapy, 23 500; more vs less surgery, 9300; more surgery vs radiotherapy, 9300). 24 types of local treatment
comparison were identified. To help relate the effect on local (ie, locoregional) recurrence to that on breast cancer
mortality, these were grouped according to whether or not the 5-year local recurrence risk exceeded 10% (<10%,
17 000 women; >10%, 25 000 women).
Findings: About three-quarters of the eventual local recurrence risk occurred during the first 5 years. In the
comparisons that involved little (<10%) difference in 5-year local recurrence risk there was little difference in
15-year breast cancer mortality. Among the 25 000 women in the comparisons that involved substantial (>10%)
differences, however, 5-year local recurrence risks were 7% active versus 26% control (absolute reduction 19%), and
15-year breast cancer mortality risks were 44·6% versus 49·5% (absolute reduction 5·0%, SE 0·8, 2p<0·00001).
Additional Metadata | |
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Persistent URL | doi.org/10.1016/S0140-6736(05)67887-7, hdl.handle.net/1765/54880 |
Journal | The Lancet |
Organisation | Department of Surgery |
Citation |
Kikuchi, K., Koyama, H., Masuda, H., Nomura, Y., Sakai, D., Sugimachi, K., … Caffier, H. (2005). Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival. The Lancet, 366(9503), 2087–2106. doi:10.1016/S0140-6736(05)67887-7 |