Experimental evidence for the beneficial effects on heart failure of chronic treatment with ACE inhibitors accumulated from early 1980 in experimental models of LV dysfunction secondary to AMI. These studies demonstrated an improvement in hemodynamics, LV remodeling, and mortality with ACE inhibitor treatment. The effect of ACE inhibitors during the acute phase of AMI was less clear, although there was evidence of protection from ischemic damage, possibly mediated by an increase in collateral coronary blood flow.

Angiotensin-Converting Enzyme Inhibitors/*therapeutic use, Humans, Myocardial Infarction/*drug therapy, Randomized Controlled Trials as Topic, Time Factors, Ventricular Dysfunction, Left/drug therapy
Circulation (Baltimore)
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Erasmus MC: University Medical Center Rotterdam

Latini, R, Maggioni, A.P, Flather, M, Sleight, P, Tognoni, G, & Simoons, M.L. (1995). ACE inhibitor use in patients with myocardial infarction. Summary ofevidence from clinical trials. Circulation (Baltimore), 92(10), 3132–3137. Retrieved from http://hdl.handle.net/1765/5509