2005-12-29
Fanconi anemia (cross)linked to DNA repair
Publication
Publication
Cell , Volume 123 - Issue 7 p. 1191- 1198
Fanconi anemia is characterized by hypersensitivity to DNA interstrand crosslinks (ICLs) and susceptibility to tumor formation. Despite the identification of numerous Fanconi anemia (FANC) genes, the mechanism by which proteins encoded by these genes protect a cell from DNA interstrand crosslinks remains unclear. The recent discovery of two DNA helicases that, when defective, cause Fanconi anemia tips the balance in favor of the direct involvement of the FANC proteins in DNA repair and the bypass of DNA lesions.
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| doi.org/10.1016/j.cell.2005.12.009, hdl.handle.net/1765/55160 | |
| Cell | |
| Organisation | Department of Molecular Genetics |
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Niedernhofer, L., Lalai, A., & Hoeijmakers, J. (2005). Fanconi anemia (cross)linked to DNA repair. Cell (Vol. 123, pp. 1191–1198). doi:10.1016/j.cell.2005.12.009 |
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