2014-02-21
Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion
Publication
Publication
Journal of Biological Chemistry , Volume 289 - Issue 8 p. 5000- 5012
Background: Periodic fever syndromes are caused by deregulation of Interleukin-1β release. Results: Defective autophagy leads to accumulation of damaged mitochondria in monocytes. Conclusion: Mitochondrial components in the cytosol cause priming of monocytes for Interleukin-1β release. Significance: The molecular mechanism behind deregulated cytokine secretion provides new clues for intervention.
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| doi.org/10.1074/jbc.M113.536920, hdl.handle.net/1765/55253 | |
| Journal of Biological Chemistry | |
| Organisation | Department of Molecular Genetics |
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van der Burgh, R., Nijhuis, L., Pervolaraki, K., Compeer, E., Jongeneel, N., van Gijn, M., Coffer, P., Murphy, M., Mastroberardino, P., Frenkel, J.& Boes, M. (2014). Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion. Journal of Biological Chemistry, 289(8), 5000–5012.https://doi.org/10.1074/jbc.M113.536920 |
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