2005-11-01
Resolution of EBV+ CNS lymphoma with appearance of CSF EBV-specific T cells
Publication
Publication
Annals of Neurology , Volume 58 - Issue 5 p. 788- 792
Current knowledge of Epstein-Barr virus (EBV)-specific T-cell responses in the cerebrospinal fluid (CSF) of patients with EBV-related lymphoproliferative disease (EBV-LPD) in the central nervous system (CNS) is very limited. Here, we present two recipients of hematopoietic stem cell transplants with EBV-LPD in the CNS. EBV-specific CD8+ T lymphocytes were detected in CSF and peripheral blood using major histocompatibility complex (MHC) class I multimers loaded with EBV-derived peptides. The appearance of EBV-specific CD8+ T cells in CSF and blood correlated with neurological improvement and disappearance of EBV-LPD. These observations suggest a role for EBV-specific CD8+ T cells in the control of EBV-LPD in the CNS.
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| doi.org/10.1002/ana.20640, hdl.handle.net/1765/55392 | |
| Annals of Neurology | |
| Organisation | Department of Immunology |
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de Beukelaar, J., van Arkel, C., van den Bent, M., van 't Veer, M., van Doornum, G., Cornelissen, J., … Gratama, J.-W. (2005). Resolution of EBV+ CNS lymphoma with appearance of CSF EBV-specific T cells. Annals of Neurology, 58(5), 788–792. doi:10.1002/ana.20640 |
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