2006-02-01
Methionine metabolism and phenotypic variability in X-linked adrenoleukodystrophy
Publication
Publication
Neurology , Volume 66 - Issue 3 p. 442- 443
A combined genotype of polymorphisms of methionine metabolism has been associated with CNS demyelination in methotrexate-treated patients. Within a sample of 86 patients with X-linked adrenoleukodystrophy, this genotype was overrepresented in a subgroup of 15 patients with adrenomyeloneuropathy (AMN) with CNS demyelination (adrenoleukomyeloneuropathy) in comparison to 49 AMN patients without CNS demyelination ("pure" AMN; p = 0.002), suggesting that methionine metabolism might contribute to the phenotypic variability in adrenoleukodystrophy. Copyright
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| doi.org/10.1212/01.wnl.0000196491.42058.6f, hdl.handle.net/1765/55420 | |
| Neurology | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Linnebank, M., Kemp, S., Wanders, R., Kleijer, W., van der Sterre, M., Gärtner, J., Fliessbach, K., Semmler, A., Sokolowski, M., Köhler, W., Schlegel, U., Schmidt, S., Klockgether, T.& Wüllner, U. (2006). Methionine metabolism and phenotypic variability in X-linked adrenoleukodystrophy. Neurology, 66(3), 442–443.https://doi.org/10.1212/01.wnl.0000196491.42058.6f |
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