Proteases are essential for the proliferation and growth of bacteria, and are also known to contribute to bacterial virulence. This makes them interesting candidates as diagnostic and therapeutic targets for infectious diseases. In this review, the authors discuss the most recent developments and potential applications for bacterial proteases in the diagnosis and treatment of bacterial infections. Current and future bacterial protease targets are described and their limitations outlined.

doi.org/10.1007/s10096-014-2075-1, hdl.handle.net/1765/56072
European Journal of Clinical Microbiology & Infectious Diseases: an international journal on pathogenesis, diagnosis, epidemiology, therapy, and prevention of infectious diseases
Department of Medical Microbiology and Infectious Diseases

Kaman, W., Hays, J., Endtz, H., & Bikker, F. (2014). Bacterial proteases: Targets for diagnostics and therapy. European Journal of Clinical Microbiology & Infectious Diseases: an international journal on pathogenesis, diagnosis, epidemiology, therapy, and prevention of infectious diseases (Vol. 33, pp. 1081–1087). doi:10.1007/s10096-014-2075-1