Background: Plasma concentrations of atrial natriuretic peptides are correlated with atrial pressures, as are left ventricular ejection fraction and left ventricular filling abnormalities. Aims: This study investigated the relation of atrial natriuretic peptides to both left ventricular systolic and diastolic function in heart failure. Methods: Plasma concentrations of atrial natriuretic peptide and N-terminal pro-atrial natriuretic peptide were measured in 63 patients with chronic heart failure and left ventricular systolic dysfunction. According to Doppler transmitral flow measurements, 19 patients had a restrictive and 44 patients had a non-restrictive left ventricular filling pattern. Results: Plasma concentrations of atrial natriuretic peptide and N-terminal pro-atrial natriuretic peptide were higher in patients with a restrictive filling pattern than in patients with a non-restrictive filling pattern (197 vs. 75 pmol/l, P < 0.0001 and 1.14 vs. 0.45 nmol/l, P < 0.0001). In univariate analysis, atrial natriuretic peptide and N-terminal pro-atrial natriuretic peptide correlated with deceleration time, E/A ratio and left ventricular ejection fraction. In multivariate analysis, both peptides appeared independently related to left ventricular ejection fraction and left ventricular filling pattern. Conclusion: In patients with chronic heart failure, atrial natriuretic peptides provide information on left ventricular systolic as well as diastolic function.

atrial natriuretic peptide, heart failure, left ventricular ejection fraction, left ventricular filling pattern, n-terminal pro-atrial natriuretic peptide
dx.doi.org/10.1016/S1388-9842(98)00005-1, hdl.handle.net/1765/5613
European Journal of Heart Failure
Erasmus MC: University Medical Center Rotterdam

Wijbenga, J.A.M, Balk, A.H.M.M, Jonkman, F.A.M, Simoons, M.L, Man in 't Veld, A.J, & Boomsma, F. (2000). Relation of atrial natriuretic peptides to left ventricular systolic and diastolic function in heart failure. European Journal of Heart Failure, 1(1), 51–58. doi:10.1016/S1388-9842(98)00005-1