2000-09-01
Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection
Publication
Publication
Nature Medicine , Volume 6 - Issue 9 p. 1036- 1042
Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in human immunodeficiency virus (HIV)-1 infected individuals, suggesting for thymic impairment. Here, we show that in healthy individuals, declining thymic output will affect the TREC content only when accompanied by naive T-cell division. The rapid decline in TRECs observed during HIV-1 infection and the increase following HAART are better explained not by thymic impairment, but by changes in peripheral T-cell division rates. Our data indicate that TREC content in healthy individuals is only indirectly related to thymic output, and in HIV-1 infection is mainly affected by immune activation.
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| doi.org/10.1038/79549, hdl.handle.net/1765/56228 | |
| Nature Medicine | |
| Organisation | Department of Immunology |
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Hazenberg, M. D., Otto, S., Stuart, J. W. T. C., Verschuren, M., Borleffs, J. W., Boucher, C., Coutinho, R., Lange, J., Rinke de Wit, T., Tsegaye, A., van Dongen, J., Hamann, D., de Boer, R.& Miedema, F. (2000). Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection. Nature Medicine, 6(9), 1036–1042.https://doi.org/10.1038/79549 |
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