We studied the natural course of high-risk human papillomavirus (HPV) infection and cytological regression in women referred for colposcopy because of abnormal cervical smears. We found that high-risk HPV clearance preceded regression of cervical lesions by an average of 3 months. The cumulative 1-year rate of cytological regression was similar in women with mild and moderate dyskaryotic cervical smears. Thus, retesting of high-risk HPV after 6 months in women with mild to moderate dyskaryosis predicts cytological regression.

doi.org/10.1016/S0140-6736(01)06809-X, hdl.handle.net/1765/56345
The Lancet
Department of Gynaecology & Obstetrics

Nobbenhuis, M., Helmerhorst, T., van den Brule, A. J. C., Rozendaal, L., Voorhorst, F., Bezemer, P. D., … Meijer, C. (2001). Cytological regression and clearance of high-risk human papillomavirus in women with an abnormal cervical smear. The Lancet, 358(9295), 1782–1783. doi:10.1016/S0140-6736(01)06809-X