Ultrasound contrast agents oscillate approximately linearly up to a certain pressure range where nonlinearity sets in. Nonlinear microbubble oscillations are exploited in ultrasound pulse-echo imaging as this improves the contrast-to-tissue ratio. Here we report the observation of a highly nonlinear response of phospholipid-coated contrast agents at pressures as low as 50 kPa, termed "compression-only" behavior, where the microbubbles only compress, yet hardly expand. Time-resolved bubble dynamics recorded through ultra high-speed imaging revealed that nearly 40% of the coated bubbles show "compression-only" behavior. (E-mail: n.dejong@erasmusmc.nl).

doi.org/10.1016/j.ultrasmedbio.2006.09.016, hdl.handle.net/1765/56565
Ultrasound in Medicine & Biology
Department of Cardio-Thoracic Surgery

de Jong, N., Emmer, M., Chin, C., Bouakaz, A., Mastik, F., Lohse, D., & Versluis, M. (2007). "Compression-Only" Behavior of Phospholipid-Coated Contrast Bubbles. Ultrasound in Medicine & Biology, 33(4), 653–656. doi:10.1016/j.ultrasmedbio.2006.09.016