OBJECTIVE: To describe the results of thrombolysis prior to hospitalisation in patients with evolving myocardial infarction. DESIGN: Prospective cohort study. METHOD: The 'Reperfusion for acute infarcts Rotterdam' (Dutch acronym: REPAIR) programme aims to minimise treatment delay in patients with evolving myocardial infarction by the initiation of thrombolytic therapy prior to hospital admission. For patients with symptoms that indicate a developing myocardial infarction, treatment is initiated immediately by the ambulance personnel at the patient's home, once the diagnosis has been confirmed with the help of a portable 12-lead ECG system. The interval between the onset of symptoms and the thrombolysis infusion was recorded for all patients, as well as any complications which occurred during transportation. The long-term survival was determined using data from the municipal registration. RESULTS: In the period 1988-2000, 1487 patients were treated using the REPAIR protocol, 80% of these within two hours after the onset of symptoms. In 9 cases (0.6%) a thrombolytic treatment had been initiated, whereas the diagnosis 'myocardial infarction' was not confirmed at the hospital. During transport 40 patients (2.7%) experienced ventricle fibrillation, 25 (1.7%) severe hypotension, and 2 patients (0.1%) died. Mortality at 30 days and at one, five, and ten years was 4.9%, 7.3%, 16.2% en 30.1%, respectively. Patients treated within two hours after the onset of symptoms had lower mortality rates than those treated later: at one year 6.7% versus 9.7%, and at 5 years 14.0% versus 25.1% (Kaplan-Meier estimates; log rank test: p = 0.001). CONCLUSION: Immediate thrombolytic treatment of patients with a developing myocardial infarction which could be safely initiated by ambulance personnel, resulted in excellent short-term and long-term survival.

Additional Metadata
Keywords *Triage, Aged, Electrocardiography, Emergency Medical Services, English Abstract, Female, Follow-Up Studies, Human, Male, Middle Aged, Myocardial Infarction/*diagnosis/*drug therapy/mortality, Netherlands/epidemiology, Prospective Studies, Survival Rate, Telemetry, Thrombolytic Therapy/*methods, Time Factors
Persistent URL hdl.handle.net/1765/5666
Journal Nederlands Tijdschrift voor Geneeskunde
Ilmer, B, Vos, J, Simoons, M.L, Maas, A.C.P, Hartman, J.A.M, & Boersma, H. (2001). 12 jaar triage en trombolytische behandeling voor ziekenhuisopname bij hartinfarctpatienten in de regio Rotterdam: uitstekende korte- en langetermijnresultaten. Nederlands Tijdschrift voor Geneeskunde, 145, 2029–2035. Retrieved from http://hdl.handle.net/1765/5666