Virus-specific cytotoxic T lymphocytes (CTL) play a major role in the clearance of respiratory syncytial virus (RSV) infection. We have generated cytotoxic T-cell clones (TCC) from two infants who had just recovered from severe RSV infection. These TCC were functionally characterized and used to identify HLA class I (B57 and C12)-restricted CTL epitopes of RSV.

, , , , , , , , , , , , , , ,,
Journal of Virology
Department of Virology

Brandenburg, A., de Waal, L., Timmerman, H., Hoogerhout, P., de Swart, R., & Osterhaus, A. (2000). HLA class I-restricted cytotoxic T-cell epitopes of the respiratory syncytial virus fusion protein. Journal of Virology, 74(21), 10240–10244. doi:10.1128/JVI.74.21.10240-10244.2000