The process of learning involves stable changes in synaptic efficacy for which long term potentiation (LTP) provides a widely adopted mammalian model. Synaptic modification induced by learning or LTP may involve the action of cell adhesion molecules. One such candidate is the ubiquitous neuronal glycoprotein Thy-1 (refs 5, 6). In mice in which the gene encoding Thy-1 has been inactivated, we find a regionally selective impairment of LTP in vivo in the hippocampal formation: LTP is normal in area CA1 but strongly inhibited in the dentate gyrus. Spatial learning by Thy-1-deficient mice, as assessed in the watermaze, is unimpaired. Thus LTP in the cortical input to the dentate gyrus seems not to be required for spatial learning.,
Nature: international weekly journal of science
Biophysical Genomics, Department Cell Biology & Genetics

Nosten-Bertrand, M., Errington, M., Murphy, K. P. S. J., Tokugawa, Y., Barboni, E., Kozlova, E., … Morris, R. (1996). Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1. Nature: international weekly journal of science, 379(6568), 826–829. doi:10.1038/379826a0