We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This allele was also associated with an increased risk of myoclonus. Our findings suggest that there may be differences in progression and clinical appearance in early-onset AD related to the APOE genotype.

, , , , , , , , , , , ,
hdl.handle.net/1765/5757
Journal of Neurology: official journal of the European Neurological Society
Erasmus MC: University Medical Center Rotterdam

Bronzova, J., van Duijn, C., Havekes, L. M., de Knijff, P., van Broeckhoven, C., & Hofman, A. (1996). Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease. Journal of Neurology: official journal of the European Neurological Society, 243, 465–468. Retrieved from http://hdl.handle.net/1765/5757