We have studied the relationship between the apolipoprotein E gene (APOE) and the development of myoclonus, tremors, rigidity and seizures in 168 patients with probable early-onset Alzheimer's disease (AD). There was a statistically significantly lower risk of tremor for carriers of the epsilon 4 allele of APOE. This allele was also associated with an increased risk of myoclonus. Our findings suggest that there may be differences in progression and clinical appearance in early-onset AD related to the APOE genotype.

0 (Apolipoproteins), Alleles, Alzheimer Disease/*genetics/pathology, Apolipoproteins/*genetics, Comparative Study, Female, Human, Male, Middle Aged, Prognosis, Support, Non-U.S. Gov't, dementia
hdl.handle.net/1765/5757
Journal of Neurology: official journal of the European Neurological Society
Erasmus MC: University Medical Center Rotterdam

Bronzova, J.B, van Duijn, C.M, Havekes, L.M, de Knijff, P, van Broeckhoven, C, & Hofman, A. (1996). Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease. Journal of Neurology: official journal of the European Neurological Society, 243, 465–468. Retrieved from http://hdl.handle.net/1765/5757