The potential human health effects of bisphenol A (BPA) exposure are a public health concern. In order to design adequately powered epidemiological studies to address potential health effects, data on the reproducibility of BPA concentration in serial urine specimens taken during pregnancy are needed. To provide additional data on the reproducibility of maternal urine specimens, 80 women in the Generation R Study (Rotterdam, The Netherlands) contributed a spot urine specimen at o18, 18–25, and 425 weeks of pregnancy. Reproducibility, estimated by the intraclass correlation coefficient (ICC), was 0.32 (95% confidence interval: 0.18–0.46), and, on a creatinine basis, 0.31 (95% confidence interval: 0.16–0.47). Although the ICC observed in the Generation R Study is slightly higher than previous reproducibility studies of BPA, it nevertheless indicates a high degree of within-person variability that presents challenges for designing well-powered epidemiologic studies.

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doi.org/10.1038/jes.2014.23, hdl.handle.net/1765/57584
Journal of Exposure Science and Environmental Epidemiology
Erasmus MC: University Medical Center Rotterdam

Jusko, T. A., Shaw, P., Snijder, C., Pierik, F., Koch, H. M., Hauser, R., … Longnecker, M. (2014). Reproducibility of urinary bisphenol A concentrations measured during pregnancy in the Generation R Study. Journal of Exposure Science and Environmental Epidemiology. doi:10.1038/jes.2014.23