2003-03-01
PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease
Publication
Publication
Annals of Neurology , Volume 53 - Issue 3 p. 409- 412
We analyzed the PRNP M129V polymorphism in a Dutch population-based early-onset Alzheimer's disease sample. We observed a significant association between early-onset Alzheimer's disease and homozygosity of M129V (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.1-3.3; p = 0.02) with the highest risk for V homozygotes (OR, 3.2; 95% CI, 1.4-7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3-5.3; p < 0.01) and 3.5 (95% CI, 1.3-9.3; p = 0.01), respectively.
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| doi.org/10.1002/ana.10507, hdl.handle.net/1765/57710 | |
| Annals of Neurology | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Dermaut, B., Croes, E., Rademakers, S., van Broeckhoven, C., Cruts, M., Hofman, A., … van Broeckhoven, C. (2003). PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease. Annals of Neurology, 53(3), 409–412. doi:10.1002/ana.10507 |
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