Objectives: We studied the diagnostic performance of 64-slice computed tomography coronary angiography (CTCA) to rule out or detect significant coronary stenosis in patients referred for valve surgery. Background: Invasive conventional coronary angiography (CCA) is recommended in most patients scheduled for valve surgery. Methods: During a 6-month period, 145 patients were prospectively identified from a consecutive patient population scheduled for valve surgery. Thirty-five patients were excluded because of CTCA criteria: irregular heart rhythm (n = 26), impaired renal function (n = 5), and known contrast allergy (n = 4). General exclusion criteria were: hospitalization in community hospital (n = 4), no need for CCA (n = 4), previous coronary artery bypass surgery (n = 1), or percutaneous coronary intervention (n = 4). Of the remaining 97 patients, 27 denied written informed consent. Thus, the study population comprised 70 patients (49 male, 21 female; mean age 63 ± 11 years). Results: Prevalence of significant coronary artery disease, defined as having at least 1 ≥50% stenosis per patient, was 25.7%. Beta-blockers were administered in 71%, and 64% received lorazepam. The mean heart rate dropped from 72.5 ± 12.4 to 59.5 ± 7.5 beats/min. The mean scan time was 12.8 ± 1.3 s. On a per-patient analysis, the sensitivity, specificity, and positive and negative predictive values were: 100% (18 of 18; 95% confidence interval [CI] 78 to 100), 92% (48 of 52; 95% CI 81 to 98), 82% (18 of 22; 95% CI 59 to 94), and 100% (48 of 48; 95% CI 91 to 100), respectively. Conclusions: The diagnostic accuracy of 64-slice CTCA for ruling out the presence of significant coronary stenoses in patients undergoing valve surgery is excellent and allows CTCA implementation as a gatekeeper for invasive CCA in these patients.

doi.org/10.1016/j.jacc.2006.06.054, hdl.handle.net/1765/57779
Journal of the American College of Cardiology
Department of Cardio-Thoracic Surgery

Meijboom, W. B., Mollet, N., van Mieghem, C., Kluin, J., Weustink, A., Pugliese, F., … de Feyter, P. (2006). Pre-Operative Computed Tomography Coronary Angiography to Detect Significant Coronary Artery Disease in Patients Referred for Cardiac Valve Surgery. Journal of the American College of Cardiology, 48(8), 1658–1665. doi:10.1016/j.jacc.2006.06.054