The synthesis of14C labelled arachidonic acid metabolites was measured in colonic tissues obtained from mice, rats, guinea pigs, rabbits, piglets and in colonic biopsies from humans during colonoscopy. The main eicosanoids formed after stimulation with calcium ionophore A23187 were: in humans, 15-hydroxy-eicosatetraenoic acid (15-HETE); in mice, 12-HETE; in rats, 12-HETE, 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and 6-keto-prostaglandine F1α (6kPGF1α); in guinea pigs, PGD2; in rabbits, 6kPGF1α, PGE2 and 15-HETE; and in pigs PGE2 and 12-HETE. In inflamed 15-HETE production was increased in man, HHT and 12-HETE production in rats and overall eicosanoid production in mice.

doi.org/10.1007/BF01991027, hdl.handle.net/1765/57806
Inflammation Research
Department of Internal Medicine

Zijlstra, F., van Dijk, A., Garrelds, I., Ouwendijk, R., & Wilson, P. (1992). Species differences in the pattern of eicosanoids produced by inflamed and non-inflamed tissue. Inflammation Research, 36(1 Supplement). doi:10.1007/BF01991027