A human genomic fragment comprising the cellular retinoic acid binding protein (CRABP) gene was isolated. By using a panel of somatic cell hybrids, this gene could be assigned to human chromosome 15. Subsequently, a possible involvement of the CRABP gene in translocation (15;17) (q22;q11) positive acute promyelocytic leukemia (APL) was investigated. Although transposition of the CRABP gene could be demonstrated, we did not observe any gross CRABP rearrangement in a series of primary APL patients, nor in the acute myeloblastic leukemia cell line HL-60. Thus, the observed lack of CRABP expression in these leukemic cells may not be caused by disruption of its gene. CRABP maps to the region 15q22-qter.

doi.org/10.1007/BF00204182, hdl.handle.net/1765/57937
Human Genetics
Biophysical Genomics, Department Cell Biology & Genetics

Geurts van Kessel, A., de Leeuw, H., Dekker, E. J., Rijks, J., Spurr, N., Ledbetter, A. M., … Vaessen, M.-J. (1991). Localization of the cellular retinoic acid binding protein (CRABP) gene relative to the acute promyelocytic leukemia-associated breakpoint on human chromosome 15. Human Genetics, 87(2), 201–204. doi:10.1007/BF00204182