BACKGROUND: Cisplatin is considered safe to use during the second and third trimesters of pregnancy in patients with cancer. CASE: A 34-year-old pregnant woman was diagnosed with cervical cancer. She received five weekly dosages of cisplatin and paclitaxel, starting at 26 5/7 weeks of gestation. An elective cesarean delivery was performed at 34 4/7 weeks of gestation. After birth, the neonate was diagnosed with severe bilateral perceptive hearing loss. CONCLUSION: Cisplatin during the second and third trimesters of pregnancy may lead to fetal ototoxicity.,
Obstetrics and Gynecology
Department of Gynaecology & Obstetrics

Geijteman, E., Wensveen, C., Duvekot, H., & van Zuylen, L. (2014). A child with severe hearing loss associated with maternal cisplatin treatment during pregnancy. Obstetrics and Gynecology, 124(2 PART2), 454–456. doi:10.1097/AOG.0000000000000389