Here we report the observation of a highly non-linear bubble response of phospholipid coated contrast agents, termed 'compression-only behavior' where the microbubbles only compress, yet hardly expand. The occurrence of this phenomenon has been studied retrospectively and it was found that 33% of the examined cases show this behavior. The compression-only behavior is described by a newly developed shell model for phospholipid coated bubbles. The model extends previous elastic models with shell compressibility, a buckling radius and a break-up tension. It also predicts large amplitude oscillations, and bubble break-up.

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2005 IEEE Ultrasonics Symposium
Department of Cardiology

van der Meer, S., de Jong, N., Marmottant, P., Hilgenfeldt, S., Versluis, M., Lohse, D., … Emmer, M. (2005). Highly non-linear contrast agent oscillations: The compression-only behavior. Presented at the 2005 IEEE Ultrasonics Symposium. doi:10.1109/ULTSYM.2005.1603012