Postprandial inflammation is considered to be pro-atherogenic. Vitamin D can reduce inflammation and arterial stiffness. We hypothesized that vitamin D3 improves postprandial arterial elasticity by the modulation of leukocyte activation. Healthy volunteers underwent two oral fat-loading tests (OFLTs). The augmentation index (AIx) and flow cytometric quantification of leukocyte activation markers were measured. After the first OFLT, 100 000 IU of vitamin D3 was administered and a second OFLT was carried out 7 days later. Six men and six women were included. A favorable reduction in AIx was found after vitamin D3 supplementation (P=0.042) in both genders. After vitamin D3, exclusively in women a reduction in the area under the postprandial curve for monocytes CD11b and CD35 by 10.5% (P=0.016) and 12.5% (P=0.04) and neutrophil CD11b by 17.0% (P=0.014) was observed. In conclusion, vitamin D3 probably increased postprandial arterial elasticity in men and women, but reduced postprandial leukocyte activation exclusively in women.,
European Journal of Clinical Nutrition
Department of Cardiology

Klop, B., van de Geijn, G.-J., Birnie, E., Njo, T., Janssen, H., Jansen, H. G., … Castro Cabezas, M. (2014). Vitamin D3 mediated effects on postprandial leukocyte activation and arterial stiffness in men and women. European Journal of Clinical Nutrition, 68(5), 635–637. doi:10.1038/ejcn.2014.29