Several studies have reported an association of the apolipoprotein E allele epsilon 4 (APOE*4) to familial and sporadic late-onset Alzheimer's disease (LOAD). Here we report on the relationship between APOE*4 and early-onset Alzheimer's disease (EOAD) in a Dutch population-based study. The frequency of the APOE*4 allele was 2.3 times higher among EOAD cases compared to controls. Among patients, the allele frequency was 1.6 times higher in those with a positive family history than in those without. A significant increase in risk of EOAD was found for subjects homozygous for APOE*4 regardless of family history of dementia, but an increase in EOAD risk for APOE*4 heterozygotes could only be shown in subjects with a positive family history. Our study demonstrates a significant association between APOE*4 and EOAD which is modified by family history of dementia.

*Alleles, 0 (Apolipoproteins E), 0 (apolipoprotein E-4), Adult, Age of Onset, Aged, Alzheimer Disease/epidemiology/*genetics, Apolipoproteins E/*genetics, Family Health, Female, Gene Frequency, Genes, Dominant, Genotype, Human, Male, Middle Aged, Netherlands/epidemiology, Odds Ratio, Polymerase Chain Reaction, Risk Factors, Support, Non-U.S. Gov't, dementia
hdl.handle.net/1765/5808
Nature Genetics
Erasmus MC: University Medical Center Rotterdam

van Duijn, C.M, de Knijff, P, Cruts, M, Wehnert, A, Havekes, L.M, van Broeckhoven, C, & Hofman, A. (1994). Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease. Nature Genetics, 7, 74–78. Retrieved from http://hdl.handle.net/1765/5808