2005-11-01
Serum uric acid levels and the risk of Parkinson disease
Publication
Publication
Annals of Neurology , Volume 58 - Issue 5 p. 797- 800
In a prospective population-based cohort study among 4,695 participants aged 55 years and older, with repeated in-person examination and on average 9.4 years of follow-up, we observed that higher serum levels of uric acid were associated with a significantly decreased risk of Parkinson disease (adjusted hazard ratio per standard deviation increase 0.71 [95% confidence interval 0.51-0.98]), with evidence for a dose-effect relationship (p value for trend over quartiles 0.040). Our findings support the hypothesis that oxidative stress contributes to the risk of Parkinson disease and suggest a potential protective effect of the natural antioxidant and free radical scavenger uric acid.
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| doi.org/10.1002/ana.20663, hdl.handle.net/1765/58080 | |
| Annals of Neurology | |
| Organisation | Department of Neurology |
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de Lau, L., Koudstaal, P., Hofman, A., & Breteler, M. (2005). Serum uric acid levels and the risk of Parkinson disease. Annals of Neurology, 58(5), 797–800. doi:10.1002/ana.20663 |
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