Videodensity of left heart and right heart were studied after intravenous injection of increasing dosages of 0.01-0.02 and 0.04 mL/kg bodyweight of Albunex® in 10 healthy volunteers. The increase in videodensity in the left ventricle was always lower than in the right ventricle. Possible explanations are diffusion of gases caused by ambient pressures changes and change in microspheres distribution due to the sieving effect of the lung capillary bed. These phenomena were studied in vitro and were consistent with clinical observations. These limitations restrict a quantitative assessment of left heart echocontrast after intravenous injection.,
Ultrasound in Medicine & Biology
Department of Cardiology

de Jong, N, ten Cate, F.J, Vletter, W.B, & Roelandt, J.R.T.C. (1993). Quantification of transpulmonary echocontrast effects. Ultrasound in Medicine & Biology, 19(4), 279–288. doi:10.1016/0301-5629(93)90100-3