1990-08-01
Identification of β2-adrenoceptors on guinea pig alveolar macrophages using (-)-3-[125I]iodocyanopindolol
Publication
Publication
Inflammation , Volume 14 - Issue 4 p. 421- 426
The β-adrenoceptor antagonist (-)-3-[125I]iodocyanopindolol ([125I]ICYP) binds with high affinity and in a saturable way to membranes of guinea pig alveolar macrophages. The equilibrium dissociation constant for [125I]ICYP is 24.3 ± 1.2 pM, and the number of binding sites is 166.3 ± 13.7 fmol/mg protein (N=4, ±SEM). Displacement studies with selective antagonists showed that [125I]ICYP labels β2-adrenoceptors on guinea pig alveolar macrophages.
| Additional Metadata | |
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| doi.org/10.1007/BF00914093, hdl.handle.net/1765/58399 | |
| Inflammation | |
| Organisation | Department of Pharmacology |
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Leurs, R., Beusenberg, F. D., Bast, R., van Amsterdam, J., & Timmerman, H. (1990). Identification of β2-adrenoceptors on guinea pig alveolar macrophages using (-)-3-[125I]iodocyanopindolol. Inflammation, 14(4), 421–426. doi:10.1007/BF00914093 |
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