1994
Prognostic factors in renal-cell carcinoma: Immunohistochemical detection of p53 protein versus clinico-pathological parameters
Publication
Publication
International Journal of Cancer , Volume 57 - Issue 5 p. 634- 637
Immunoreactivity forp53 protein was assessed in 100 cases of primary renal-cell carcinoma (RCC). The results were correlated with clinical survival data (follow-up 24 to 84 months: mean: 39 months) and with clinico-pathological parameters, including nuclear grade, tumour stage, cell type, tumour architecture and tumour diameter. In all, 32% of the tumours were p53-positive; there was no difference in survival between p53-positive and -negative cases. Similarly, p53 expression did not correlate with any of the clinico-pathological parameters mentioned. Nuclear grade (grade 1 + 2 vs. grade 3 + 4) had a striking impact on prognosis and so, to a lesser extent, did tumour stage and the occurrence of a spindle-cell component. The immunohistochemical detection of p53 in RCC is not of prognostic value. The estimation of nuclear grade, however is a major predictor of prognosis.
| Additional Metadata | |
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| doi.org/10.1002/ijc.2910570504, hdl.handle.net/1765/58406 | |
| International Journal of Cancer | |
| Organisation | Department of Pathology |
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Bot, F., Godschalk, J. C. J., Krishnadath, K., van der Kwast, T., & Bosman, F. (1994). Prognostic factors in renal-cell carcinoma: Immunohistochemical detection of p53 protein versus clinico-pathological parameters. International Journal of Cancer, 57(5), 634–637. doi:10.1002/ijc.2910570504 |
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