2006-03-01
T-sing progenitors to commit
Publication
Publication
Trends in Immunology , Volume 27 - Issue 3 p. 125- 131
T-cell development in the thymus is a complex and highly regulated process. During the process of differentiation from multipotent progenitor cells to mature T cells, proliferation, restriction of lineage potential, TCR gene rearrangements and selection events occur, all accompanied by changes in gene expression. A comprehensive understanding of thymocyte differentiation remains to be established. Two related, key issues have received much attention recently: the nature of the thymus seeding cell and the regulation of T-cell lineage commitment. Here we review the perspectives of different researchers working both on murine and human T-cell development and argue that a true T-cell commitment factor might not be required because of the unique properties of the thymus.
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doi.org/10.1016/j.it.2006.01.006, hdl.handle.net/1765/58505 | |
Trends in Immunology | |
Organisation | Department of Immunology |
Weerkamp, F., Pike, K., & Staal, F. (2006). T-sing progenitors to commit. Trends in Immunology (Vol. 27, pp. 125–131). doi:10.1016/j.it.2006.01.006 |