Lipid content is a key factor in vulnerable atherosclerotic plaques that may lead to myocardial infarction. Intravascular photoacoustic (IVPA) imaging is a possible method to identify lipid content in the artery wall. We developed a method to automatically detect lipids in human coronary atherosclerosis using spectroscopic IVPA. In cross-sectional IVPA/intravascular ultrasound (IVUS) scans of fresh ex vivo human coronary arteries, we correlated the photoacoustic spectra to a reference lipid spectrum in the 1200 nm spectral range. Correlation coeffcients above a certain cut-off value indicated similarity between IVPA and reference lipid spectra. Automatically detected lipid areas exhibited good correspondence with the histological lipid stain of the same cross section.

atherosclerosis, intravascular photoacoustics, intravascular ultrasound, lipids, spectroscopy, tissue characterization, vulnerable plaque
dx.doi.org/10.1109/ULTSYM.2012.0009, hdl.handle.net/1765/58506
2012 IEEE International Ultrasonics Symposium, IUS 2012
Erasmus MC: University Medical Center Rotterdam

Jansen, K, van der Steen, A.F.W, van Beusekom, H.M.M, Springeling, T, Wu, M, Mastik, F, & van Soest, G. (2012). Automatic lipid detection in human coronary atherosclerosis using spectroscopic intravascular photoacoustic imaging. Presented at the 2012 IEEE International Ultrasonics Symposium, IUS 2012. doi:10.1109/ULTSYM.2012.0009