High-dose chemoradiotherapy combined with autologous bone marrow transplantation can cure patients with disseminated, aggressive non-Hodgkin's lymphoma in whom first-line chemotherapy has failed. In contrast, cure is rare with second-line chemotherapy. It has been suggested that patients with slow responses to the initial phase of first-line chemotherapy are at high risk for relapse. Therefore, such patients are potential candidates for early bone marrow transplantation.

doi.org/10.1056/NEJM199504203321601, hdl.handle.net/1765/58548
New England Journal of Medicine
Department of Hematology

Verdonck, L., van Putten, W., Hagenbeek, A., Schouten, H., Sonneveld, P., van Imhoff, G., … Löwenberg, B. (1995). Comparison of chop chemotherapy with autologous bone marrow transplantation for slowly responding patients with aggressive non-Hodgkin's lymphoma. New England Journal of Medicine, 332(16), 1045–1051. doi:10.1056/NEJM199504203321601