To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genome-wide analyses of these data are consistent with a long tail of additional common variant loci explaining much of the variation in susceptibility to T2D. Exploration of the enlarged set of susceptibility loci implicates several processes, including CREBBP-related transcription, adipocytokine signaling and cell cycle regulation, in diabetes pathogenesis.

dx.doi.org/10.1038/ng.2383, hdl.handle.net/1765/58733
Nature Genetics
Department of Surgery

Morris, A.P, Voight, B.F, Teslovich, T.M, Ferreira, T, Segrè, A.V, Steinthorsdottir, V, … McCarthy, M.I. (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics, 44(9), 981–990. doi:10.1038/ng.2383