A 47 year old man is described who developed pathology proven Creutzfeldt-Jakob disease (CJD) 38 years after receiving a low dose of human derived growth hormone (hGH) as part of a diagnostic procedure. The patient presented with a cerebellar syndrome, which is compatible with iatrogenic CJD. This is the longest incubation period described so far for iatrogenic CJD. Furthermore, this is the first report of CJD after diagnostic use of hGH. Since the patient was one of the first in the world to receive hGH, other cases of iatrogenic CJD can be expected in the coming years.

12629-01-5 (Human Growth Hormone), Age of Onset, Creutzfeldt-Jakob Disease, Creutzfeldt-Jakob Syndrome/diagnosis/*etiology/pathology, Human, Human Growth Hormone/*adverse effects/diagnostic use, Iatrogenic Disease, Male, Middle Aged, Support, Non-U.S. Gov't, Time Factors
dx.doi.org/10.1136/jnnp.72.6.792, hdl.handle.net/1765/5880
Journal of Neurology, Neurosurgery and Psychiatry: an international peer-reviewed journal for health professionals and researchers in all areas of neurology and neurosurgery
Erasmus MC: University Medical Center Rotterdam

Croes, E.A, Roks, C.M.A.A, Jansen, G.H, Nijssen, P.C, & van Duijn, C.M. (2002). Creutzfeldt-Jakob disease 38 years after diagnostic use of human growth hormone. Journal of Neurology, Neurosurgery and Psychiatry: an international peer-reviewed journal for health professionals and researchers in all areas of neurology and neurosurgery, 72(6), 792–793. doi:10.1136/jnnp.72.6.792