2006-05-01
An Insulin-Like Growth Factor-I Promoter Polymorphism Is Associated With Increased Mortality in Subjects With Myocardial Infarction in an Elderly Caucasian Population
Publication
Publication
The American Journal of Cardiology , Volume 97 - Issue 9 p. 1274- 1276
We investigated whether an insulin-like growth factor I (IGF-I) promoter polymorphism is associated with excess mortality in elderly subjects with myocardial infarction (MI). This association was assessed in 7,983 subjects of the Rotterdam Study during 14 years of follow-up. Among 345 subjects who developed a MI, the risk of mortality was 1.49 times higher in the variant carriers of the IGF-I promoter polymorphism than in the nonvariant carriers (95% confidence interval 1.10 to 2.10, p = 0.02). The risk of death increased with the number of variant alleles. Our study suggests that genetically determined low IGF-I activity is an important determinant of mortality in subjects with MI.
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doi.org/10.1016/j.amjcard.2005.11.069, hdl.handle.net/1765/58808 | |
The American Journal of Cardiology | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Yazdanpanah, M., Rietveld, I., Janssen, J., Njajou, O., Hofman, A., Stijnen, T., … van Duijn, C. (2006). An Insulin-Like Growth Factor-I Promoter Polymorphism Is Associated With Increased Mortality in Subjects With Myocardial Infarction in an Elderly Caucasian Population. The American Journal of Cardiology, 97(9), 1274–1276. doi:10.1016/j.amjcard.2005.11.069 |