university website

H. Houlden (Henry), M. Stevens (Martijn), P. de Knijff (Peter), C.M. van Duijn (Cornelia), P. Heutink (Peter), J. Perez-Tur (Jordi), V. Thomas (Valerie), M.C. Baker (Matthew), H. Morris (Huw), M. Rossor (Martin), et al. J.C. Jannsen (John), R.C. Petersen (Ronald), P. Dodd (Peter), F. Dark (Frances), B.F. Boeve (Bradley), D. Dickson (Dennis), P. Davies (Peter), S. Pickering-Brown (Stuart), D. Mann (David), J. Adamson (Jennifer), T. Lynch (Tim), H. Payami (Haydeh), P. Poorkaj (Parvoneh), T.D. Bird (Thomas), G.D. Schellenberg (Gerard), S. Chadraverty, J. Norton (Joanne), F.C. Morris (Huw), A.M. Goate (Alison), M. Hutton (Michael), J. Hardy (John), P. Rizzu (Patrizia) and J.C. van Swieten (John)

1999-02-05

Apolipoprotein E genotype does not affect the age of onset of dementia in families with define tau mutations

Publication

Publication

Neuroscience Letters , Volume 260 - Issue 3 p. 193- 195

We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype.

Additional Metadata
Keywords 0 (Apolipoproteins E), 0 (tau Proteins), Age of Onset, Aged, Apolipoproteins E/*genetics, Chromosomes, Human, Pair 17/genetics, Dementia/*genetics/psychology, Frontal lobe dementia, Genotype, Human, Middle Aged, Mutation, Missense/physiology, Parkinson Disease/genetics, Support, Non-U.S. Gov't, Support, U.S. Gov't, P.H.S., tau Proteins/*genetics
Persistent URL doi.org/10.1016/S0304-3940(98)00931-8, hdl.handle.net/1765/5886
Journal Neuroscience Letters
Organisation Erasmus MC: University Medical Center Rotterdam
Full Text ( Final Version )


User Publication Person Organisation Collection
Close