We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype.

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doi.org/10.1016/S0304-3940(98)00931-8, hdl.handle.net/1765/5886
Neuroscience Letters
Erasmus MC: University Medical Center Rotterdam

Houlden, H, Stevens, M, de Knijff, P, van Duijn, C.M, Heutink, P, Perez-Tur, J, … van Swieten, J.C. (1999). Apolipoprotein E genotype does not affect the age of onset of dementia in families with define tau mutations. Neuroscience Letters, 260(3), 193–195. doi:10.1016/S0304-3940(98)00931-8