Two new loci, PARK6 and PARK7, for autosomal recessive early-onset parkinsonism have recently been identified on chromosome 1p, in single large pedigrees. Among 4 autosomal recessive early-onset families analyzed here, 2 supported linkage to PARK7, 1 with conclusive evidence. These data confirm localization of autosomal recessive early-onset parkinsonism to PARK7, suggesting it to be a frequent locus. Assignment of families to either PARK6 or PARK7 might be difficult because of the proximity of the two loci on chromosome 1p.

*Chromosomes, Human, Pair 1, *Ubiquitin-Protein Ligases, Adult, Age of Onset, EC 6. (Ligases), EC 6.3.2.19 (Ubiquitin-Protein Ligases), EC 6.3.2.19 (parkin protein), Family Health, Female, Human, Ligases/genetics, Lod Score, Male, Middle Aged, Parkinson's disease, Parkinsonian Disorders/*genetics, Pedigree, Support, Non-U.S. Gov't
dx.doi.org/10.1002/ana.10106, hdl.handle.net/1765/5900
Annals of Neurology
Erasmus MC: University Medical Center Rotterdam

Bonifati, V, Breedveld, G.J, Squitieri, F, Vanacore, N, Brustenghi, P, Harhangi, B.S, … Rizzu, P. (2002). Localization of autosomal recessive early-onset parkinsonism to chromosome 1p36 (PARK7) in an independent dataset. Annals of Neurology, 51(2), 253–256. doi:10.1002/ana.10106