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M. Cnop (M.), S.J. Hughes (S.), M. Igoillo-Esteve (M.), M.B. Hoppa (M.), F. Sayyed (F.), L. van de Laar (Lianne), J.H. Gunter (J.), E.J. de Koning (Eelco), A.F. Walls, D.W.G. Gray (D. W G), et al. P.R.V. Johnson (Paul), B.C. Hansen. (B.), J.F. Morris (J.), M. Pipeleers-Marichal (M.), I. Cnop (I.) and A. Clark (A.)

2010-02-01

The long lifespan and low turnover of human islet beta cells estimated by mathematical modeling of lipofuscin accumulation

Publication

Publication

Diabetologia: clinical and experimental diabetes and metabolism , Volume 53 - Issue 2 p. 321- 330

Aims/hypothesis Defects in pancreatic beta cell turnover are implicated in the pathogenesis of type 2 diabetes by genetic markers for diabetes. Decreased beta cell neogenesis could contribute to diabetes. The longevity and turnover of human beta cells is unknown; in rodents <1 year old, a half-life of 30 days is estimated. Intracellular lipofuscin body (LB) accumulation is a hallmark of ageing in neurons. To estimate the lifespan of human beta cells, we measured beta cell LB accumulation in individuals aged 1-81 years.

Additional Metadata
Persistent URL doi.org/10.1007/s00125-009-1562-x, hdl.handle.net/1765/59189
Journal Diabetologia: clinical and experimental diabetes and metabolism
Grant This work was funded by the European Commission 7th Framework Programme; grant id fp7/223211 - Collaborative European effort to Develop Diabetes Diagnostics (CEED3)
Organisation Department of Internal Medicine
Citation
Cnop, M., Hughes, S., Igoillo-Esteve, M., Hoppa, M., Sayyed, F., van de Laar, L., … Clark, A. (2010). The long lifespan and low turnover of human islet beta cells estimated by mathematical modeling of lipofuscin accumulation. Diabetologia: clinical and experimental diabetes and metabolism, 53(2), 321–330. doi:10.1007/s00125-009-1562-x


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