PURPOSE: To examine the relation among serum cholesterol, apolipoprotein E genotype (APOE), and the risk of early and late age-related macular degeneration (AMD). DESIGN: The Rotterdam Study, a population based prospective cohort study. METHODS: Serum levels of total and high-density lipoprotein (HDL) cholesterol as well as APOE genotype were determined at baseline. Of 3,944 subjects, 400 were diagnosed with incident early and late AMD after a mean follow-up of 5.2 years. RESULTS: Serum HDL, but not total, cholesterol was associated with an increased risk of AMD (odds ratio/SD, 1.20; 95% confidence interval; 1.06-1.35). The association remained unchanged after adjustment for APOE genotype. When stratifying for APOE genotype, the association was strongest in persons with the e 4 allele; an inverse association seemed to be present for e 2 carriers. CONCLUSION: Elevated HDL but not total cholesterol is associated with an increased risk of AMD. Apolipoprotein E genotype does not explain this association but may be an effect modifier.

Additional Metadata
Keywords 0 (Apolipoproteins E), 0 (Lipoproteins, HDL Cholesterol), 57-88-5 (Cholesterol), Apolipoproteins E/genetics, Cholesterol/*blood, Genotype, Human, Lipoproteins, HDL Cholesterol/blood, Macular Degeneration/*blood/etiology/genetics, Middle Aged, Ophthalmologic disease, Prospective Studies, Risk Factors, Support, Non-U.S. Gov't
Persistent URL dx.doi.org/10.1016/j.ajo.2003.09.015, hdl.handle.net/1765/5923
Journal American Journal of Ophthalmology
Citation
Vingerling, J.R, Hofman, A, van Duijn, C.M, Stricker, B.H.Ch, de Jong, P.T.V.M, van Leeuwen, R, & Klaver, C.C.W. (2004). Cholesterol and age-related macular degeneration: is there a link?. American Journal of Ophthalmology, 137(4), 750–752. doi:10.1016/j.ajo.2003.09.015