An acoustical method was developed to retrieve the radial response of single microbubbles to a pressure wave by means of a low-amplitude probing wave. If the frequency of the latter is much higher than the spherical resonance frequency of the microbubble, the relative amplitude modulation in the signal scattered in response to the probing wave is quasi-equal to the radial strain induced by the pressure wave. A reference probe signal before and after the transmission of the pressure wave allows us to assess asymmetry in microbubble oscillations. Among 138 lipid-coated microbubbles, 8 and 7 showed compression-only and expansion-only behaviors, respectively.

dx.doi.org/10.1063/1.3693522, hdl.handle.net/1765/59354
Applied Physics Letters
Department of Cardio-Thoracic Surgery

Renaud, G, Bosch, J.G, van der Steen, A.F.W, & de Jong, N. (2012). An "acoustical camera" for in vitro characterization of contrast agent microbubble vibrations. Applied Physics Letters, 100(10). doi:10.1063/1.3693522