A series of 195 random chromosome 22-specific probes, equivalent to approximately 1% of the size of this chromosome, have been isolated from a chromosome 22-specific bacteriophage lambda genomic library. These probes were mapped to four different regions of chromosome 22 on a panel of five somatic cell hybrids. Restriction fragment length polymorphisms were detected by 28 of the probes mapping to 22q12-qter. Evolutionarily conserved sequences in human, mouse, and Chinese hamster DNA were detected by 12% of the isolated probes.

dx.doi.org/10.1007/BF00200562, hdl.handle.net/1765/59372
Human Genetics
Department of Medical Microbiology and Infectious Diseases

Dumanski, J.P, Geurts van Kessel, A.H.M, Ruttledge, M, Wladis, A, Sugawa, N, Collins, V.P, & Nordenskjöld, M. (1990). Isolation of anonymous, polymorphic DNA fragments from human chromosome 22q12-qter. Human Genetics, 84(3), 219–222. doi:10.1007/BF00200562