1992
Hydrocortisone-induced increase of PDGF β-receptor expression in a human malignant mesothelioma cell line
Publication
Publication
Experimental Cell Research: emphasizing molecular approaches to cell biology , Volume 200 - Issue 1 p. 83- 88
The effect of hydrocortisone (HC) on PDGF β-receptor expression was studied in the human malignant mesothelioma cell line Mero-14. HC was found to induce a time- and dose-dependent increase of PDGF β-receptor mRNA. Nuclear run off analysis revealed that HC induced increased transcription of the PDGF β-receptor gene. The expression of PDGF β-receptor protein was also elevated by HC as demonstrated with an immunoblotting assay. However, the number of PDGF-BB binding sites on the cell surface of Mero-14 remained unchanged upon HC treatment. These results suggest that steroid hormones can regulate PDGF receptor expression in vivo.
| Additional Metadata | |
|---|---|
| doi.org/10.1016/S0014-4827(05)80074-6, hdl.handle.net/1765/59587 | |
| Experimental Cell Research: emphasizing molecular approaches to cell biology | |
| Organisation | Department of Immunology |
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Versnel, M., Bouts, A., Langerak, A., van der Kwast, T., Hoogsteden, H., Hagemeijer, A., & Heldin, C. (1992). Hydrocortisone-induced increase of PDGF β-receptor expression in a human malignant mesothelioma cell line. Experimental Cell Research: emphasizing molecular approaches to cell biology, 200(1), 83–88. doi:10.1016/S0014-4827(05)80074-6 |
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