The influence of neck thrombus on clinical outcome and aneurysm morphology after endovascular aneurysm repair

Objective: This study investigated the influence of significant aneurysm neck thrombus in clinical and morphologic outcomes after endovascular aneurysm repair (EVAR). Methods: The patient population was derived from a prospective EVAR database from two university institutions in The Netherlands from 2004 to 2008. Patients with significant thrombus in the neck (>2 mm in thickness in at least >25% of circumference) were identified as the thrombus group and were compared with the remaining patients without neck thrombus (no-thrombus group), treated within the same period. The primary end point was clinical success. Secondary end points included technical success and rates of decline in renal function. Detailed morphologic analysis of the aortic neck was serially performed for the thrombus group patients to assess changes in thrombus volume. Results: The study included 389 patients: 43 (39 men; mean age of 72.3 years) met the criteria for the thrombus group; of these, 31 (72%) had significant thrombus in >50% of the aortic neck circumference, and 8 (19%) had circumferential thrombus >2-mm thick. Median follow-up was 3.34 years (interquartile range, 2.67-4.72). The estimated 5-year clinical success rate was 74% for the thrombus group and 62% for the no-thrombus group (P =.23). Endograft migration was more frequent in the thrombus group (P =.02). Multivariable Cox regression analysis showed a significant association between migration and use of a device without active fixation (hazard ratio, 4.9; 95% confidence interval, 1.31-18.23; P =.018) but not with the presence of neck thrombus (P =.063). No differences were found in the rates of decline in estimated glomerular filtration rate at 30 days and during follow-up between the thrombus and no-thrombus groups. The thrombus volume in the first 10 mm of aortic neck was progressively reduced over time until it was not measurable in most patients, resulting in complete circular attachment of the endograft to the vessel wall. Conclusions: Our findings suggest that the presence of aneurysm neck thrombus has no significant influence on short-term and midterm EVAR results.

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dissertation Endovascular Aortic Repair F.M.V. Bastos Gonçalves (Frederico)