2013-06-03
Role of T cell immunity in hepatitis C virus infections
Publication
Publication
Current Opinion in Virology , Volume 3 - Issue 4 p. 461- 467
Chronic infections with the hepatitis C virus (HCV) are a major global health issue. Viral replication is restricted to hepatocytes, and occurs for decades at high replication rates. Over the last decade, it became accepted that HCV-specific CD4+ and CD8+ T cells are crucial for protective immunity to HCV. However, a characteristic feature of persistent HCV infection is the dysfunctional T cell response, and over recent years enormous progress has been made in understanding the mechanisms that dampen the antiviral T cell responses in blood and liver of chronic HCV patients and also impact disease progression.
Additional Metadata | |
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doi.org/10.1016/j.coviro.2013.05.006, hdl.handle.net/1765/59611 | |
Current Opinion in Virology | |
Organisation | Department of Gastroenterology & Hepatology |
Claassen, M., Janssen, H., & Boonstra, A. (2013). Role of T cell immunity in hepatitis C virus infections. Current Opinion in Virology, 3(4), 461–467. doi:10.1016/j.coviro.2013.05.006 |