We studied 4,963 participants of the population-based Rotterdam Study and found that a genetically determined chronic exposure to low insulin-like growth factor-I (IGF-I) levels is associated with an increased risk for heart failure in elderly patients.

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doi.org/10.1016/j.amjcard.2004.04.044, hdl.handle.net/1765/5978
The American Journal of Cardiology
Erasmus MC: University Medical Center Rotterdam

Bleumink, G., Rietveld, I., Janssen, J., van Rossum, L., Hofman, A., van Duijn, C., … Deckers, J. (2004). Insulin-like growth factor-I gene polymorphism and risk of heart failure (the Rotterdam Study). The American Journal of Cardiology, 94(3), 384–386. doi:10.1016/j.amjcard.2004.04.044