Using the rat anti-müllerian hormone type II receptor (AMHRII) cDNA as a probe, two overlapping lambda phage clones containing the AMHRII gene were isolated from a human genomic library. Sequence analysis of the exons was performed and the exon/intron boundaries were determined. The coding region was found to consist of 11 exons, divided over 8 kb. The genomic structure resembles that of the related activin type II receptor gene. The AMHRII gene was mapped to human chromosome 12q12-q13. The results reported are essential for identification of AMHRII gene alterations in patients with persistent müllerian duct syndrome.

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Persistent URL dx.doi.org/10.1006/bbrc.1995.2567, hdl.handle.net/1765/59900
Journal Biochemical and Biophysical Research Communications
Citation
Visser, J.A, McLuskey, A, van Beers, T, Weghuis, D.O, Geurts van Kessel, A.H.M, Grootegoed, J.A, & Themmen, A.P.N. (1995). Structure and chromosomal localization of the human anti-mullerian hormone type II receptor gene. Biochemical and Biophysical Research Communications, 215(3), 1029–1036. doi:10.1006/bbrc.1995.2567